Using its knowledge of Spider-Man and his alter-ego, Venom attacked and nearly defeated Spider-Man, but was eventually stopped and separated from Brock. Angered, he accepted to bond with the Symbiote in the hopes of getting revenge on the Wall-Crawler. Having investigated a crime, Brock had been tricked into reporting a scapegoat until Spider-Man arrested the true culprit. Left to die, Venom instead survived by bonding with disgraced reporter Eddie Brock. When Venom's nature began to kill him, Spider-Man decided to rid himself of the parasite and, using a church bell, weakened it enough to remove it. However, the parasite also incentivized the hero to user darker techniques and come close to killing criminals on multiple occasions.

Its time with the hero gave Venom access to a number of other abilities that other Symbiotes could not access, such as wall climbing and web based abilities. Eventually arriving on Battleworld, it would bond itself to the superhero Spider-Man by disguising itself as a more powerful black suit. To survive, the Symbiote that would call itself Venom bonded to a variety of hosts to survive and learned a variety of techniques. Using the decapitated head of one of his own, the Celestial created the Symbiotes and sent them to evolve around the Universe. The Venom Symbiote is believed to have been created by the Celestial Knull, along with many of its own kind. Whilst bonded, the player will be given access to a variety of powers and abilities.

Added to the Superheroes Unlimited during the merge into the Legends Mod, Venom can be accessed by committing both to the Web-Crawler and Symbiote legacies. It, likewise, has also worked with supervillains and criminals. Venom often serves as a villain to the Wall-Crawler, though has often worked with him and other superheroes in order to achieve its own goals. Unlike many of its kind, Venom is granted spider-based abilities, due to it's time bonded with the superhero Spider-Man. First appearing in The Amazing Spider-Man #252 (May 1984), it is an alien Symbiote and that bonds to other creatures to survive. Venom is a supervillain/anti-hero published by Marvel Comics.

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